More than one way to skin . . .

There's more than one way to skin this cat.

More than one way to skin a phagosome

In This Issue In This Issue More than one way to skin a phagosome hagosome studies have rested on a major assumption: that in a given cell, all phagosomes with the same cargo mature alike. On page 185, Henry et al. test this assumption, and find it wanting. Using ratiometric fluorescence microscopy, the authors followed the maturation of individual macrophage phago-somes containing IgG-opsonize...

There's More than One Way to Skin a Chimaerin

In two manuscripts published in Neuron (Beg et al. and Wegmeyer et al.) and one published in Cell (Iwasato et al.), investigators have found that a particular GAP, alpha-chimaerin, is required in vivo for ephrinB3/EphA4-dependent motor circuit formation.

More Than One Way to Skin a Catenin

eled that in turn interferes with glycogen synthase kinase The targeted destruction of proteins is a highly con3 (GSK3 ). This is the serine/threonine kinase that served process employed by cells to regulate a number phosphorylates those all-important residues in the reguof vital functions (Tyers and Willems, 1999). The translatory sequence of -catenin. The kinase does not act port of nutrients...

More than one way to go.

D ramatic changes accompany the death of cells. Attempts to align these changes into cognate groups and identify the mechanisms responsible for them have led to substantial and sometimes surprising insights into cell biology. One such constellation of structural and functional changes is associated with apoptosis (a death process found in development, atrophy, the targets of cell killing by the...